Solved by a verified expert:11. Which is true of a drug target?a. It may be the site of actionb. It may be the site of inhibitionc. A & Bd. None of the above12. You have sequenced the DNA of a new pathogen and will use computers to interpret this sequences. This is called?a. Computational Chemistryb. Bioinformaticsc. Biostatisticsd. Immunology13. Good choices to design drugs to target in a bacteria would include?a. Sites / Areas known for growthb. Sites / Areas known for survivalc. A & Bd. None of the above14. In creating a drug to kill a pathogen (e.g., bacteria) it is important that the drug:a. Kill the pathogenb. Create little harm (or kill) the patientc. A & Bd. None of the above15. Sites for “attacking” a pathogen could include?a. Pathogen’s DNAb. Pathogen’s Plasma Membranec. Pathogen’s cell walld. All of the above16. Which of the following statements are true?a. Manufactures for drug production need to be certified by the FDA firstb. Each manufacturing process needs to be documentedc. A & Bd. None of the above17. Which of the following statement are factors affecting the manufacture of bio-drugs?a. Raw materials utilized in the manufacturing processb. Color-coding of the samplesc. A & Bd. None of the above18. Which of the following is true about an ideal drug?a. It is efficacious (effective)b. It has very low to no toxicityc. A & Bd. None of the above19. Which of the following is a type of IND?a. Sustained Useb. Non-conformingc. A & Bd. None of the above20. Which of the following are questions to be considered in drug development?a. Is the drug metabolized and if so, to what?b. Is the drug cytotoxic or mutagenic?c. A & Bd. None of the above21. Which federal agency regulates drug development:a. FBIb. DEAc. FDAd. Congress22. Personal medicine includes:a. Tailoring Drugs to the patient’s genotypeb. Getting to know the patient’s activitiesc. A & Bd. None of the above23. Modern Pharma companies outsource to CRO’s. What part of the drug discovery process do CRO’s handle?a. Marketingb. Productionc. Medicinal Chemistryd. Clinical Trials24. The human genome project included:a. Sequencing of the genomeb. Determining the function of all human genesc. Both A & Bd. None of the above25. John is accepted into a clinical trial, which are true?a. He must be given a copy of the informed consent paperb. He must sign the informed consent paperc. A & Bd. None of the above26. Which might cause a drug trial to come to a halt?a. 10% of the participants die because of the drugb. The CEO of the drug company is charged with embezzlementc. A & Bd. None of the above27. When does a participant in a drug trial receive a physical?a. Before the trialb. After the trialc. A & Bd. None of the above28. Which phase of the clinical trial normally has the least number of participants?a. Phase Ib. Phase IIc. Phase IIId. Phase IV29. Which phase of the clinical trial ONLY looks at side effects?a. Phase Ib. Phase IIc. Phase IIId. Phase IV30. Which of the following phases of the clinical trial would include the fewest participants?a. Phase Ib. Phase IIc. Phase IIId. Phase IV31. Why are clinical trials performed?a. To test new drugs to see if they work against diseaseb. To meet requirements that all pharma companies create 10 new drugs per yearc. Both A & Bd. None of the above32. Which is true about informed consent?a. It must be written at a 10th grade level of Englishb. It must be written in at least 10 languagesc. Both A & Bd. None of the above33. Which phase of a clinical trial occurs after the drug has been released?a. Phase Ib. Phase IIc. Phase IIId. Phase IV34. Which is true about toxicity?a. In ALL cases toxicity seen in a clinical trial causes suspension of the trialb. If the toxicity compared to the reward of the drug is much less a clinical trial will not be suspendedc. Both A & Bd. None of the above35. Which phase of the clinical trial ONLY looks at side effects?a. Phase I b. Phase IIc. Phase IIId. Phase IV36. Which is true about informed consent?a. It must be written at a 10th grade level of Englishb. It must be written in at least 10 languagesc. Both A & Bd. None of the above37. Which “phase” of a clinical trial occurs after the drug has been released?a. Phase Ib. Phase IIc. Phase IIId. Phase IV38. Which of the following must be disclosed in informed consent documents?a. Patient may quit at any timeb. Hourly reimbursement for participationc. A & Bd. None of the above39. Which of the following statement are factors affecting the manufacture of bio-drugs?a. Raw materials utilized in the manufacturing processb. Color-coding of the samplesc. A & Bd. None of the above40. Which is not an International Drug Classa. Hallucinogensb. Inhalantsc. Sunscreend. Dissociative Anesthetics41. Which is not a Narcotic Analgesica. Codeinb. Demerolc. Oxycontind. All are narcotic analgesics42. Pilot studies in manufacturing:a. Are not used in drug manufacturingb. Act as a “test run” for large scale-upc. A & Bd. None of the above43. Why is the drug industry so large?a. People get sickb. Baby-boomers are getting olderc. A & Bd. None of the above44. Drug companies and purchase drug targets from Biotech Companies by:a. Upfront Paymentb. Royaltiesc. Equityd. All of the above45. Which is true of hiring a CROa. The CRO always provides credit ($)b. The CRO has poor network of sites to find patientsc. A & Bd. None of the Above46. Which is not an economic classification of a drug?a. Blockbusterb. Orphanc. Epic Faild. All are economic classifications47. When choosing a drug or disease to work on, the pharmaceutical companies take into consideration:a. Market Potentialb. Competitionc. A & Bd. None of the Above48. What percentage of Drug Targets are G-protein Coupled Receptors?a. 26.8b. 13.0c. 13.4d. 46.849. Which drugs are central nervous system depressants?a. Alcoholb. Aspirinc. A & Bd. None of the Above50. Which is an average time-line for the development of a drug?a. 1 – 3 yearsb. 5 – 8 yearsc. 10 – 12 yearsd. 25 – 30 years
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