Description Competitive inhibition of enzymes has the mechanism E+S?X (k1 forward, k-1 reverse) X à P + E (k2) E+I?EI (k3 forward, k-3 reverse) XI ?X +I (k4 forward, k-4 reverse) 1. Write the expression for d[X]/dt (you do not need to solve this or simplify it). 2. For the above reaction [E]0= 3. = is the solution to this mechanism. If you did a Lineweaver Burke plot of this equation, the slope would be________________ and the intercept would be__________________. 4. The initial rates of enzyme reactions level off with increasing substrate concentration because: (you should evaluate whether each of the following statements are true or not and be able to explain your reasoning). a. too much substrate inhibits the reaction b. at high substrate concentration all the enzyme is tied up with substrate c. the substrate reacts with the products at high concentrations d. the steady state approximation fails 5.Consider a polymer formed by a chain process. By how much does the kinetic chain length change if the concentration of initiator decreases by a factor of 10.0 and the concentration of monomer increases by a factor of 5.0? 6.If you had ethylene glycol and adipic acid as your compounds to form a stepwise (condensation) polymer, show what the structure of the polymer would look like. Ethylene glycol is HOCH2CH2OH Adipic acid is 7.The first-order rate constant for the decomposition of a certain substance is 1.70×10–2 s–1 at 30ºC and 2.88×10–2 s–1 at 37ºC. Determine the activation energy and Arrhenius constant. Also calculate the activation parameters. Please see the attached file project 3+4 which has the rest of questions.
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