Expert answer:Survival factors inhibit apoptosis by activating t

  

Solved by a verified expert:Survival factors inhibit apoptosis by activating the signaling pathway mediated by the lipid kinase PI3K are the serine/theronine kinase Akt.a. How would apoptosis be affected in cells with a mutation in the survival signal receptor causing the receptors to always be dimerized?b. How would apoptosis be affected in cells with a constitutively active form of Akt and a Ser -> Ala mutation at the only Ser or Thr in the Bad protein?c. The PI3K-Akt signaling pathway also promotes self-renewal of embryonic stem (ES) cells by inhibiting apoptosis. How would the stem cell population be affected in ES cells with a dominant-negative mutation in PI3K?

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