Expert answer:In the citric acid cycle, the dehydrogenation of m

  

Solved by a verified expert:In the citric acid cycle, the dehydrogenation of malate into oxaloacetate is quite unfavorable in terms of energy. Incoming acetyl Co-A reacts with oxaloacetate to form citrate via citrate synthase, thereby depleting oxaloacetate. If the conversion of malate into oxaloacetate is so unfavorable, then why does it happen?

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