Expert answer:Examination of the ABO gene shows that exon 6

  

Solved by a verified expert:Examination of the ABO gene shows that exon 6 (which contains the allelic variant .0001 SNP) is near the downstream end of the gene as it appears on the chromosome. However, the loss of enzyme function associated with the O allele was due to a deletion near the beginning (upstream end) of the coding sequence of the gene. Explain the apparent contradiction

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