I need help creating a thesis and an outline on The Use of Beta-blockers and ACE Inhibitors or Endothelin Receptor Antagonist and ACE Inhibitors as Combination Therapy for Heart Failure. Prepare this

  

I need help creating a thesis and an outline on The Use of Beta-blockers and ACE Inhibitors or Endothelin Receptor Antagonist and ACE Inhibitors as Combination Therapy for Heart Failure. Prepare this assignment according to the guidelines found in the APA Style Guide. An abstract is required. A new paradigm was therefore taken to combining the three independent interventions in a manner that mad the presence of ACE inhibitors constant. The resulting combined therapies that were produced were ACE inhibitors and beta-blockers, ACE inhibitors, and endothelin receptors, antagonists. Different tests were conducted on patients with heart failure to find out the most preferred inclusion and exclusion criteria that work for different patients when attempting to use any of the combined therapies. This critical review showed that when used independently, the three therapies produced less effective results as compared to combined therapies, with the combination therapy applying ACE inhibitors and beta-blockers being the more effective combination therapy than ACE inhibitors and endothelin receptor antagonists.Cardiovascular diseases are considered one of the major health issues afflicting a significant degree of the human population. This disease has high mortality rates and has been known to lead to various health complications. However, for the most part, this disease is also very preventable and manageable. In the current setting where different major health advancements have been made and evidence-based practice highlights the importance of preventative medical care, the management of this disease has significantly improved. The primary prevention of cardiovascular diseases has been prioritized by the World Health Organization. Primary prevention includes the adoption of a healthy diet and participation in physical activities. Pharmacological management, mostly through beta blockers and ace inhibitors have been recommended for heart failure.Heart failure, otherwise known as congestive heart failure is one of the possible outcomes of cardiovascular diseases. In instances when it is not immediately managed and resolved, it can be potentially fatal. Due to the fatal nature of the disease, health authorities have expanded the research and development for CVDs and CHF, especially in terms of effective treatment and interventions for the disease.&nbsp. Some of these developments include combination therapies that ultimately seek to manage the symptoms of the disease as well as to prevent fatal outcomes of CHF.&nbsp. In a recent study by Raya, Gay, Aguirre, and Goldman (2009), it was pointed out that single interventions to heart failures have only been effective in controlling the signs and of the disease, but these interventions are not effective in improving CHF outcomes. As such, combined therapies have been suggested as better options for patients.&nbsp. In these therapies, &nbsp.two independent management solutions are combined as a single effective treatment for heart failure. In the current study, two of the most commonly used combined interventions will be discussed and evaluated. These two combined interventions are (1) beta-blockers and ace inhibitors, and (2) endothelin receptor antagonist and ace inhibitors. These therapies shall be tested against each other in order to establish which combination therapy is more effective in managing CHF.&nbsp.